Where the Dose Came From
1,500mg is where my testing settled: my own tests, and what I saw directly in the people I tested with. No study was used to set it. I tested different DHM amounts on myself, holding the formula's other ingredients constant and varying just the DHM, starting from 300mg. Amounts below 1,000mg were dropped.
Acts by promoting aldehyde and alcohol metabolism of foods.†
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
What the Best-Known Study Did
The 2012 paper by Shen and colleagues is the best-known DHM study 1. It was a study in rats, using injected DHM, mostly at 1 mg/kg, with doses from 0.3 to 10 mg/kg given alongside alcohol. It found that DHM counteracted alcohol intoxication and withdrawal signs, and it pointed to the brain's GABA-A receptors as the reason. It did not measure ADH, ALDH or acetaldehyde, and it gives no human dose.
Why a Rat Study Cannot Set a Human Dose
Animal-to-human dose translation is not a 1:1 multiplication, and for DHM it breaks down before it starts. The doses in the Shen paper's main experiments were injected, not swallowed. DHM is poorly absorbed when swallowed, at least in animals 2, and I have found no published study of how it is absorbed in people. So no conversion from that paper gives a dose anyone has tested in people, and none was used for ours.
How the Testing Worked
Triggers the liver to produce more of the aldehyde- and alcohol-metabolizing enzymes (ADH and ALDH) and boosts their efficiency in breaking down aldehydes and alcohols in foods as well as their by-products.†
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The testing ran between 2019 and 2023: about 150 tests on myself first, then over 400 with a small group of other people. They ran in ordinary drinking conditions, not a lab, and they were not blinded. The data are not study-grade and are not published. They decided the dose; they do not show how well it works.
Why 1,500mg Specifically
I settled on 1,500mg, because going higher did not justify the cost per serving. That is a formulating decision, not a finding that 1,500mg works better than a smaller amount.
Helps you feel fresh.†
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Why This Is Hard to Communicate
The 1,500mg number can look like a marketing flourish. The honest version is short: it came from testing, the testing was not a clinical study, and no study was used to set it. A label has no room for that, which is why it lives here.
For the cluster-level treatment of DHM dose-response, see DHM Dose-Response. For what is known about how DHM is absorbed, see DHM Bioavailability.