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Hangover Products Compared: What Each Study Can Tell You, What Each Contains

Cheers Restore, HANGOVR180®, Morning Recovery, No Days Wasted DHM Detox and ZBiotics Pre-Alcohol, checked the same way, with the source of every fact. None of the five has published scores from a hangover questionnaire, with the scale stated, both with and without the product, HANGOVR180® included (searches of 1 to 2 October 2026).

Who published this

This page is published by HANGOVR180®, which sells one of the five products compared here. It sets out what each product's published studies can and can't tell a buyer, and what can be checked about what each product contains. It does not claim that HANGOVR180® works better than the others.

Because HANGOVR180® has an interest in how this page reads, every statement about another product is a quote from that company's own website or study, a number from it, something it does not report, or a quote from a third party's published document about it, each with its source and the date it was read. Statements about research are quoted from the published reviews, agencies and journals named beside them. HANGOVR180®'s own words only connect these facts, draw arithmetic from them, or describe HANGOVR180®.

Last checked: 1 to 4 October 2026 · Corrections: info@hangovr180.com · Change log: see Methods, sources and changes

The answer in 30 seconds

Three questions to decide by

  1. According to its published results, how much does each product help? See The evidence, product by product, and The five products.
  2. What can you verify about what you'd be taking: the ingredients, the amounts, and whether a laboratory has confirmed them? See What each product contains, and Patent to product.
  3. Which of those matters more to you? See How to choose.

What hangover researchers have found

Reviews of hangover treatments, from 2005 to 2025:

Year Review What it covered Its words
2005Systematic review, BMJ [Pittler 2005]8 randomized controlled trials of 8 interventions; searches to January 2005"No compelling evidence exists to suggest that any conventional or complementary intervention is effective for preventing or treating alcohol hangover." (Abstract, Conclusions)
2020Alcohol Hangover Research Group [Verster 2020a]The group's ten years of research"Despite a clear demand from drinkers who experience hangovers, currently there are no hangover treatments where the effectiveness has been demonstrated in independent double-blind, placebo-controlled clinical trials."
2021Hangover researchers (Verster and colleagues), Addictive Behaviors [Verster 2021]82 hangover products"A review of scientific literature revealed no peer-reviewed human data demonstrating either safety or efficacy of any of the 82 evaluated hangover products." (Abstract)
2022Systematic review, Addiction [Roberts 2022]"A total of 21 studies were included reporting on 386 participants.""Only very low quality evidence of efficacy is available to recommend any pharmacologically active intervention for the treatment or prevention of alcohol-induced hangover." (Abstract, Conclusions)
2025Hangover researchers (Verster and colleagues), Drug Science, Policy and Law [Verster 2025]Products on the 2024 US market"...there is no proof of efficacy and safety from double-blind, placebo-controlled clinical trials in humans for any of the products available at the 2024 US hangover market." (Discussion)

These reviews cover hangover treatments and products as a group. The checks of each product on this page are HANGOVR180®'s own, made on 1 to 2 October 2026.

The 2025 paper's authors declare consultancies with companies including Sen-Jam Pharmaceutical, Toast! and Liquid IV [Verster 2025, Declaration of Conflicting Interests].

On DHM (dihydromyricetin), researchers disagree. Cheers Restore, No Days Wasted DHM Detox and HANGOVR180® list DHM as an ingredient, and More Labs' DHM page says Morning Recovery "is formulated with DHM" [More Labs, DHM page]. DHM is also a compound in Hovenia dulcis [Lee 2024], an extract on Morning Recovery's ingredient list [More Labs, product page].

How evidence is judged

There is no single official checklist for hangover products. These are the published methods this page uses, one for each question. The selection is HANGOVR180®'s; the words are theirs.

Question Published method Its words
Was bias controlled?Cochrane risk-of-bias tool (RoB 2) [Cochrane ch. 8, Table 8.2.a]Five domains: "Bias arising from the randomization process"; "Bias due to deviations from intended interventions"; "Bias due to missing outcome data"; "Bias in measurement of the outcome"; "Bias in selection of the reported result"
How far can a result be trusted?GRADE, as used by Cochrane [Cochrane ch. 14, §14.2.1]"The GRADE approach specifies four levels of certainty: high, moderate, low and very low." "In GRADE, a body of evidence from randomized trials begins with a high-certainty rating while a body of evidence from NRSI begins with a low-certainty rating." (NRSI: non-randomized studies of interventions.)
Is a statistically significant change a meaningful one?FDA guidance on patient-reported outcomes [FDA 2009, §V.E]"Because statistical significance can sometimes be achieved for small changes in PRO measures that may not be clinically meaningful (i.e., do not indicate treatment benefit), we encourage sponsors to avoid proposing labeling claims based on statistical significance alone."
How should a hangover be rated?Hangover researchers (Verster and colleagues) [Verster 2020b, Abstract]"We therefore recommend using a 1-item overall hangover rating as primary endpoint in future hangover studies that aim to assess overall hangover severity."
What evidence supports a health claim?FTC Health Products Compliance Guidance [FTC 2022, §III.B.2]"Randomized, controlled human clinical trials (RCTs) are the most reliable form of evidence and are generally the type of substantiation that experts would require for health benefit claims."
Does ingredient research apply to a product?FTC [FTC 2022, §III.B.5]"How do the dosage and formulation of the advertised product compare to the product used in the study?"
Is a supplement checked before it is sold?FDA [FDA 2022]"Under DSHEA, FDA is not authorized to approve dietary supplements for safety and effectiveness before they are marketed."
What must a trial report include?CONSORT 2025 [Hopewell 2025, Abstract]"The CONSORT 2025 statement consists of a 30-item checklist of essential items that should be included when reporting the results of a randomised trial and a diagram for documenting the flow of participants through the trial."

Terms used on this page

Seven checks, and where each applies on this page

Each check is one a reader can make in under a minute. "On this page" lists every product it applies to, HANGOVR180® included.

1. Does a percentage come with the starting score and the scale?

2. Did the people rating their symptoms know what they took?

3. Was the hangover rated on an established scale, and is the difference big enough to matter?

4. Is the drinking reported: how much, and how fast?

5. Are all the results reported?

6. Who paid for it, and who ran it?

7. Is the evidence about this product, in people?

The evidence, product by product

One row per product, HANGOVR180® included. The columns ask what a buyer needs to know about a study: what it measured, on what scale, how big the difference was, how it was designed, and who paid. Every cell about another product is the study's or company's own words, a number from them, or something they do not report. Checked 1 to 2 October 2026.

Product What was measured, and in whom Hangover questionnaire, with its scale stated? How big was the difference, as published? Design, in the study's own words Who paid and who ran it The study's or company's own words
Cheers Restore1-to-10 ratings of energy, mental clarity, physical well-being and sleep quality, on nights people chose; 90 adults analyzed; "The cohort reported a median of 8 drinks per 30 days, with 92.6% falling in the low-risk category (0–7 drinks per week)" [Song 2026, §3.1, §3.3.2]No hangover questionnaire; "single-item, investigator-designed scales (1–10)" [Song 2026, §2.5.2]0.26 to 0.36 of a point higher on supplement nights than on nights of drinking without it; "the standardized effect sizes were small (Cohen's d = 0.20–0.32)" [Song 2026, §3.3.1, §4.2]"a decentralized, 6-week, prospective observational cohort study" [Song 2026, §2.1]; no placebo; open-label"sponsored and funded by Cheers Health"; the principal investigator "received compensation from Cheers Health" [Song 2026]"the clinical relevance of improvements of this magnitude remains uncertain" [Song 2026, §4.2]
HANGOVR180®No placebo-controlled trial of the product. Unblinded formulation testing, 2019 to 2023, results not published: its co-inventor (150 self-tests) and a small group of other people (over 400 tests); candidates scored pass or fail against a higher dose of DHMEarly self-tests: a 0-to-10 checklist modeled on the Alcohol Hangover Severity Scale, replaced early by a blended score; no scores publishedNo data publishedUnblinded; not randomized; no placeboPaid for by the company behind HANGOVR180®; run by its co-inventor"Formulation testing, not an efficacy study."
Morning RecoveryNine symptoms after one supervised drinking session; "60 eligible subjects were enrolled in the trial and were randomized"; how many finished is not reported [More Labs 2019]Names five questionnaires, including the Alcohol Hangover Severity Scale; does not say which one the nine symptoms came from, or the range the scores run onPercentages, such as "up to 80%+ better", and chart scores under 2, with no stated scale range [More Labs 2019; More Labs, science page, chart image]"a multi-site, double-blind, randomized, placebo-controlled clinical study" [More Labs 2019]More Labs: "we collaborated with Curebase to conduct" it [More Labs 2019]"Users of Morning Recovery felt up to 80%+ better than those without Morning Recovery across multiple symptoms after heavy drinking." [More Labs 2019]
No Days Wasted DHM DetoxNo human study locatedNo human studyNo human studyNo human studyNo human studyIts science page: "a living library of the research, ingredients, and mechanisms behind recovery" [No Days Wasted, science page]
ZBiotics Pre-AlcoholNo human study located. A laboratory study (PLOS ONE, 2024) and a 90-day safety study in rats (Journal of Toxicology, 2019)No human studyNo human studyLaboratory and rat studiesLaboratory study: "ZBiotics Company (ZBiotics.com) funded all research, which was entirely conducted by employees of ZBiotics" [Hassan-Casarez 2024]No human study

Cheers Restore's science page also cites a test described in its patent; see its card.

The five products

Each card has the same parts, in the same order: what its published results can tell a buyer, what the product is, what its evidence includes, what it doesn't include, who paid and who ran it, and what would change the assessment. Morning Recovery's card has two more, on its advertising claim and its drinking session, because its study reports more.

Cheers Restore

Checked 1 to 2 October 2026

  • What its published results can tell a buyer. Cheers Restore's 2026 journal study reports differences of 0.26 to 0.36 of a point on 1-to-10 ratings of energy, mental clarity, physical well-being and sleep quality that its investigators designed; no hangover questionnaire was used, and the authors write that "the clinical relevance of improvements of this magnitude remains uncertain" [Song 2026, §3.3.1, §4.2]. The patent test its science page cites rated symptoms, including "general feeling about experiencing a hangover overall", "on a scale of 1-10", and reports percentage changes ("average median percent change" of 61.1%, 56.7% and 51.1% for three formulations), not the scores [US 9,603,830].
  • What it is. Capsules: "Take 3 capsules after your last drink or before bed" [Cheers, product page]. DHM 1,200 mg per serving, with L-cysteine HCl and other ingredients [Song 2026, Table 1].
  • What its evidence includes. A study funded by Cheers Health and published in the journal Nutrients in 2026: "a decentralized, 6-week, prospective observational cohort study" [Song 2026, §2.1]. Of 111 people enrolled, 90 were analyzed, "contributing 2958 analyzable survey nights" [Song 2026, §3.1]. People chose their own nights: "No interventions were assigned; participants self-selected their behavior each night and logged it retrospectively..." [Song 2026, §2.1]. "The cohort reported a median of 8 drinks per 30 days, with 92.6% falling in the low-risk category (0–7 drinks per week)" [Song 2026, §3.3.2]. Cheers Restore's science page also cites "a human study conducted for our granted patent" in which "users of Cheers Restore felt an average of 50%+ better the next day" [Cheers, science page]; the patent describes "27 participants" testing three formulations containing DHM and N-acetyl cysteine, compared with "the same alcohol consumption scenarios without the use of the composition"; no placebo is stated [US 9,603,830].
  • What it doesn't include, in its authors' words. "...the standardized effect sizes were small (Cohen's d = 0.20–0.32), and no established minimal clinically important difference exists for these single-item scales, so the clinical relevance of improvements of this magnitude remains uncertain" [Song 2026, §4.2]. People knew when they had taken it and "may rate their well-being more favorably (open-label bias)" [Song 2026, §2.6]. "...wearable data analyses are reserved for future work and are not reported in this manuscript" [Song 2026, §2.5.1].
  • Who paid and who ran it. "This study was sponsored and funded by Cheers Health." "N.R.S. received compensation from Cheers Health as principal investigator." [Song 2026, Funding; Conflicts of Interest]
  • What would change this. The trial its authors call for: "a randomized, placebo-controlled trial to establish causality" [Song 2026, Abstract].

HANGOVR180®

Checked 4 October 2026

  • What its published results can tell a buyer. HANGOVR180® has no published study of the product in people. Its website gives its co-inventor's own account of the formulation testing, which was not blinded and whose data are not published; there has been no placebo-controlled trial of the product.
  • What it is. A single-serve pouch of three capsules: "Take three capsules before your first drink." Label: DHM 1,500 mg, S-acetyl glutathione 75 mg and fulvic acid 150 mg per serving [HANGOVR180®, What's Inside]. An independent laboratory measured 1,518.614 mg of DHM per serving in one lot (see What each product contains). That confirms the amount of DHM in that lot; it does not show how well the capsules work.
  • What its evidence includes. Formulation testing, not an efficacy study. Its purpose was to choose the ingredients and their doses. Our co-inventor ran 150 self-tests, and over 400 tests with a small group of other people, between 2019 and 2023. Each test asked whether a candidate ingredient could do the work of a higher dose of DHM alone. Early self-tests set a fixed drinking level from our co-inventor's own baseline; at that level, each candidate was scored pass or fail against the higher dose of DHM and kept only if it matched that result. About fifteen candidates became three, and the ones that passed were re-checked at higher drinking levels. None of it was blinded or published.
  • What it doesn't include. A placebo-controlled trial of the product; random assignment or blinding; results on an established hangover scale; published data.
  • Who paid and who ran it. Paid for by the company behind HANGOVR180®; run by its co-inventor.
  • What would change this. A placebo-controlled trial of the product in people, registered before it starts, run independently of HANGOVR180®, and published whatever it finds. HANGOVR180® holds any trial of its own to that standard.

Morning Recovery

Checked 1 to 2 October 2026

  • What its published results can tell a buyer. Morning Recovery's published results give percentage improvements, such as "up to 80%+ better", and scores with no stated scale range (read 1 to 2 October 2026), so a reader cannot tell from them whether the change was large or small [More Labs 2019; More Labs, science page, chart image].
  • What it is. A 3.4 fl oz ready-to-drink bottle [More Labs, label decoder]: "Take one bottle while drinking" [More Labs, product page]. Its DHM page says it "is formulated with DHM at levels aligned with clinical research (~300 mg per day)" [More Labs, DHM page]; the product page does not state an amount per bottle (read 2 October 2026).
  • What its evidence includes. A study run by More Labs with Curebase and described in a post on the company's blog dated 15 August 2019. It compared Morning Recovery with a lemonade placebo, assigned people at random, and blinded both sides: "Lemonade placebo and Morning Recovery were re-packaged in the same unlabeled bottles before the study so both administrator and participants were blinded to the beverage intake." Sixty people were enrolled and randomized, and "The study protocol was approved by Integreview Institutional review board (IRB)" [More Labs 2019]. Five of nine symptoms improved by a statistically significant margin: headaches, concentration, heart-pounding, clumsiness and anxiety. Four did not: sensitivity to light, weakness, dizziness and nausea [More Labs 2019].
  • What the post doesn't include (read 1 to 2 October 2026). The range its scores run on; either group's scores in the text; how many of the 60 finished; statistical values other than "p < 0.05"; results from the sleep and immune questionnaires it names; the overall hangover severity result; the amount of alcohol each person drank. The science page's bar chart shows the five symptoms that improved, at 67% to 80% better, with every symptom scoring under 2 without Morning Recovery, and no scale stated [More Labs, science page, chart image].
  • The claim and the advertising review. The product page says "Clinically proven to improve symptoms after drinking" and "In a clinical study, consumers felt up to 80% better than those without Morning Recovery" [More Labs, product page]. In 2021 the National Advertising Division of BBB National Programs reviewed the 80% claim after a challenge from the Council for Responsible Nutrition. It "noted that although there were statistically significant results for six symptoms, only four of six achieved 76-81 percent improvements", and recommended that the claim name those four symptoms, or drop the percentage and name all six symptoms that improved significantly. More Labs said it "will comply with NAD's recommendations". The review found the claim "scientifically formulated to help you bounce back after drinking" supported [NAD 2021]. The product page's footnote names the four symptoms [More Labs, product page]. A law firm's summary quotes the review: the "two remaining symptoms – anxiety and overall hangover severity – improved by 68 and 56 percent, respectively" [FKKS 2021]. Like the 80%, those are percentages with no stated scale range.
  • The drinking. Participants were "asked to consume a pre-measured amount of Smirnoff Vodka (containing 40% alcohol, v/v) within 1-1.5 hours". Thirty minutes later, "if 0.1% BAC was not reached, a calibration dose of alcohol was administered until 0.1% BAC level was reached" [More Labs 2019]. That level is above the 0.08% at which the US alcohol institute defines binge drinking [NIAAA Basics]. A breath or blood alcohol reading shows the level at one moment, not a hangover score (check 4), and a study at one drinking level does not test what happens at others.
  • Who paid and who ran it. More Labs: "we collaborated with Curebase to conduct a multi-site, double-blind, randomized, placebo-controlled clinical study" [More Labs 2019].
  • What would change this. A full report (the score range, both groups' scores, the number who finished, the amount of alcohol and every result), or a repeat of the trial by an independent group.

No Days Wasted DHM Detox

Checked 1 to 2 October 2026

  • What its published results can tell a buyer. No Days Wasted DHM Detox has no published results in people that HANGOVR180® located (1 to 2 October 2026).
  • What it is. Capsules in packets, "15 Packets (30 Capsules)": "Take DHM Detox during your evening or before bed, not the next day." [No Days Wasted, product page]. The US product page does not state ingredient amounts (read 2 October 2026).
  • What its evidence includes. A science page that describes itself as "a living library of the research, ingredients, and mechanisms behind recovery — not marketing claims, but peer-reviewed evidence translated into plain language" [No Days Wasted, science page].
  • What it doesn't include. A published study of the product in people (none located in web searches or on its website, 1 to 2 October 2026). The science page describes no test of DHM Detox itself (read 1 October 2026).
  • Who paid and who ran it. No study located.
  • What would change this. A published study of the product in people.

ZBiotics Pre-Alcohol

Checked 1 to 2 October 2026

  • What its published results can tell a buyer. ZBiotics Pre-Alcohol has no published results in people that HANGOVR180® located (1 to 2 October 2026); the published studies located are in the laboratory and in rats.
  • What it is. A 0.47 oz liquid bottle [ZBiotics, FAQs]: "For best results, make Pre-Alcohol your first drink of the night." [ZBiotics, product page]. It contains engineered bacteria, amount not stated, and no DHM [ZBiotics, product page].
  • What its evidence includes. A laboratory study funded by ZBiotics and published in PLOS ONE in 2024, "Engineering a probiotic Bacillus subtilis for acetaldehyde removal", using cultures and "a simulated small intestinal fluid (SIF)" [Hassan-Casarez 2024]. A 90-day repeat-dose safety study in rats [Appala Naidu 2019].
  • What it doesn't include. A published study of the product in people (none located in web searches or on its website, 1 to 2 October 2026).
  • Who paid and who ran it. "ZBiotics Company (ZBiotics.com) funded all research, which was entirely conducted by employees of ZBiotics." The authors "are paid employees of ZBiotics Company and hold stock/stock options in ZBiotics Company." [Hassan-Casarez 2024]
  • What would change this. A placebo-controlled study of the product in people.

What you can compare now

The 2025 review quoted above found "no proof of efficacy and safety from double-blind, placebo-controlled clinical trials in humans" for any product on the 2024 US market. What anyone can check today is what each product contains:

These facts tell you how much of the main ingredient you'd be taking. They don't show that a product works, or that it works better than another. This is also the comparison on which HANGOVR180® does best, which is a reason to read it with that in mind.

What each product contains

Product Main active ingredient Amount per serving, as stated Where it's stated Independent laboratory result, published Testing, in the company's words
Cheers RestoreDHM1,200 mgSong 2026, Table 1None found on its product, science or supplement-facts page (2 October 2026)"Third Party Tested" [Cheers, science page]
HANGOVR180®DHM1,500 mgLabel [HANGOVR180®, What's Inside]1,518.614 mg DHM per serving, one lot, analyzed 7 October 2025 [Alkemist Labs]—
Morning RecoveryHovenia dulcis extract and DHMNot stated per bottle; its DHM page says "~300 mg per day" [More Labs, DHM page]DHM page (read 2 October 2026)None found on its product, science or DHM page (2 October 2026)"Our manufacturing facilities are NSF-certified." [More Labs, product page]
No Days Wasted DHM DetoxDHMNot stated on the US product page—None found on its product, science or FAQ page (2 October 2026)"all of our ingredients are tested in third party labs" [No Days Wasted, FAQ]
ZBiotics Pre-AlcoholEngineered bacteria; no DHMNot stated—None found on its product, how-it-works or quality page (2 October 2026)Its quality page lists tests, including of "the quantity of viable probiotic bacteria per gram"; whether an independent laboratory runs them is not stated [ZBiotics, quality page]

A stated and laboratory-confirmed amount tells you how much of that ingredient is in a product. It does not show that the product works, or that a larger amount works better.

HANGOVR180®'s laboratory result. Alkemist Labs (Garden Grove, California) tested finished capsules from lot A239310925 by HPLC and measured dihydromyricetin at 1,518.614 mg per serving, against a specification of at least 1,500 mg: Pass. The test covered DHM only; S-acetyl glutathione and fulvic acid were not tested.

For reference: DHM amounts in published studies in people. None of these tested DHM taken with alcohol against a placebo, so none shows what amount, if any, helps a hangover.

We located no tolerable upper intake for DHM; a 2021 review says "corresponding tolerable upper limits are unknown" [Verster 2021, Abstract].

Patent to product

HANGOVR180®'s formula is the subject of US patent application 18/698,010. On 11 August 2026 the US Patent and Trademark Office issued a Notice of Allowance stating "claims 1-20 are allowed"; the patent is awaiting issue [USPTO, 18/698,010].

The examiner's reasons for allowance describe the invention as "a composition comprising dihydromyricetin; and fulvic acid, humic acid or combination thereof", and state that "One of skill in the art would not be motivated to modify the prior art components ... and arrive at the presently claimed invention with a reasonable expectation of success and identical activity." [USPTO, 18/698,010, Notice of Allowance, Reasons for Allowance]

In the reasons for allowance HANGOVR180®'s label
DihydromyricetinDHM 1,500 mg
Fulvic acid, humic acid or a combinationFulvic acid 150 mg

An allowance means the patent office found that the claims meet the requirements for a patent, including that the composition is new and not obvious. It is not a test of whether HANGOVR180® works.

What would change the assessment of any product, HANGOVR180® included

If any product on this page, HANGOVR180® included, publishes such a trial, this page will say so and the change log will record it.

How to choose, by what matters to you

The question a study should answer for a buyer is how much a product helps. Here is what each product's published results say about that:

So, in the searches of 1 to 2 October 2026, none of the five had published scores from a hangover questionnaire, with the scale stated, both with and without the product: the figures a reader would need to work out how much it helps.

Methods, sources and changes

Where to buy

HANGOVR180® is sold at hangovr180.com/stock-up.

STOCK UP

Sources

Grouped by type. Each entry gives the identifier a reader can check; the locator is in the text beside each quote.

Reviews and research groups

Methods and rules

DHM research

The products' own documents and records about them

HANGOVR180®