--- source_url: https://hangovr180.com/science/formula.md canonical_url: https://hangovr180.com/science/formula generated_at: 2026-06-28T19:53:17Z build_id: ebfcfef page_type: science-hub claim_ids: [SF-21, SF-11, SF-10] --- # THE FORMULA *The H180 formula is exactly three ingredients dosed for what each one actually contributes -- DHM at 1,500mg, S-acetyl glutathione at 75mg, and fulvic acid at 150mg, with nothing else added for the label.* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. ## What Is in the Bottle The H180 formula is three ingredients. DHM (dihydromyricetin) at 1,500mg per serving handles the upstream alcohol metabolism side. S-acetyl glutathione (SAG) at 75mg handles the downstream antioxidant restoration side. Fulvic acid at 150mg, sourced at 90 percent purity, is the cellular delivery agent that helps both of the first two cross gut and cell membranes. Nothing else is added. This is the formula. Three ingredients. (this is the part of the brand I am most stubborn about, because adding ingredients for the label is the failure mode that makes most supplement formulas worse rather than better.) ## Why Three The starting candidate list during the testing phase was 12 ingredients drawn from the published alcohol-recovery and liver-protection literature. Through structured elimination across 150 self-tests, nine of those ingredients did not measurably contribute to the morning-after symptom score and were cut. The three that remained are what is in the bottle now. For the long version of why three is the right number, see [Three Ingredients -- Why Only Three](/science/formula/three-ingredients). For the elimination protocol that produced the cuts, see [The Elimination Story](/science/formula/elimination-story). ## The Patent The H180 formula architecture (DHM at 1,500mg paired with SAG and fulvic acid as a delivery vehicle) is covered in our patent. Patent applications use clinical terminology appropriate for USPTO filings. The consumer marketing language for Hangovr180® follows separate FDA regulations for dietary supplements under DSHEA -- which is why what you read on the label sounds different from what you read in the patent. For the patent in detail, see [The Patent Explained](/science/formula/patent-explained). ## How the Three Work Together > **Claim [SF-21]:** Acts by promoting aldehyde and alcohol metabolism of foods. † > > † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. DHM accelerates how fast the liver clears ethanol and acetaldehyde [1]. SAG restores the glutathione pool that ethanol metabolism depletes [2]. Fulvic acid helps both DHM and SAG cross cellular membranes through chelation chemistry [3]. The three ingredients converge on the same downstream outcome through different mechanisms, in our self-test data and in the published mechanism literature both at least. > **Claim [SF-11]:** Elevates glutathione, the body's master antioxidant in the liver. † > > † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. > **Claim [SF-10]:** Energize your cells with improved mitochondrial function. † > > † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. For the integrated mechanism story, see [How the Three Ingredients Work Together](/science/formula/how-they-work-together). ## Why DHM Is Dosed at 1,500mg DHM has roughly 4 percent absolute oral bioavailability in standard formulations. To deliver enough usable DHM to circulation to cross the threshold where the enzyme system actually responds, the input dose has to clear the bioavailability haircut. The math works out to roughly 1,000-1,500mg of input DHM, and we land at the top of that range to keep margin for individual variation in absorption. For the dose math worked out end-to-end, see [Why 1,500mg DHM -- The Dose Logic](/science/formula/why-1500mg-dhm). ## Where the Claims Land The structure-function claims on the H180 label tie back to published mechanism literature on the three ingredients [4]. Every claim on the label maps back to a published mechanism for one of teh three ingredients in the bottle. The full mapping is in the claims cluster of this site. ## Citations 1. [Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication](https://pmc.ncbi.nlm.nih.gov/articles/PMC3292407/). pmc.ncbi.nlm.nih.gov. 2. [Effects of N-Acetylcysteine, Oral Glutathione and a Novel Sublingual GSH on Oxidative Stress Markers](https://pmc.ncbi.nlm.nih.gov/articles/PMC4536296/). pmc.ncbi.nlm.nih.gov. 3. [Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes](https://pmc.ncbi.nlm.nih.gov/articles/PMC6151376/). pmc.ncbi.nlm.nih.gov. 4. [Interventions for Preventing or Treating Alcohol Hangover -- Systematic Review of Randomised Controlled Trials](https://pmc.ncbi.nlm.nih.gov/articles/PMC1322250/). pmc.ncbi.nlm.nih.gov. ## Related Clusters - [DHM -- The Hub](/science/dhm) - [SAG -- The Hub](/science/sag) - [Fulvic Acid -- The Hub](/science/fulvic-acid) - [The Testing -- 150 Self-Experiments](/science/testing) **Written by Mark Scott** - Co-Formulator, Hangovr180® | Co-Inventor, [US Application 18/698,010](https://patents.google.com/patent/US20250073201A1) Mark Scott conducted approximately 150 personal formulation tests over six months to develop the H180 ingredient combination. [Editorial standards](/editorial-standards) --- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Hangovr180® is a dietary supplement. Individual results may vary. Consult your healthcare provider before use if you have any medical conditions or take medications. [US Application 18/698,010](https://patents.google.com/patent/US20250073201A1). Canonical: https://hangovr180.com/science/formula