--- source_url: https://hangovr180.com/science/dhm.md canonical_url: https://hangovr180.com/science/dhm generated_at: 2026-06-28T19:53:17Z build_id: ebfcfef page_type: science-hub claim_ids: [SF-21, SF-01, SF-02] --- # DHM: DIHYDROMYRICETIN *Everything we know about DHM in one place -- where it comes from, what it does in the body, how it compares to alternatives, and why it sits at the center of the H180 formula.* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. ## What DHM Is DHM (dihydromyricetin) is a flavonoid compound extracted primarily from the Japanese raisin tree (*Hovenia dulcis*). It has been part of traditional Asian medicine for roughly a thousand years, originally as a hangover-and-liver remedy made from the dried fruit and stems of the tree. Modern research caught up to traditional use slowly through the 1980s and 1990s, accelerated in the 2000s, and produced the foundational pharmacological work in the early 2010s[1]. What DHM is not, despite the supplement-marketing pitch, is a "miracle hangover cure." It is a flavonoid with a specific set of effects on liver enzymes, GABA receptors, and oxidative stress pathways. Some of those effects are well-supported in animal studies. Others have weaker human translation. The point of this section of the site is to be honest about which is which. For the longer version, see [What Is DHM](/science/dhm/what-is-dhm). ## How DHM Works at the Liver Enzyme Level The headline mechanism is enzyme induction. DHM upregulates the two liver enzymes that actually metabolize alcohol -- alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) -- and helps restore the NAD+ cofactor that ethanol metabolism depletes. The result, in published animal models, is faster clearance of both ethanol and acetaldehyde from the bloodstream after alcohol challenge. This is the part of DHM's profile that distinguishes it most cleanly from other "liver support" ingredients, most of which work as antioxidant buffers downstream of the metabolic damage rather than on the metabolism itself. (it took me about a month of reading to be confident the published animal data was clean enough to bet on, honestly.) For the full mechanism breakdown, see [How DHM Works: The ADH/ALDH Pathway](/science/dhm/adh-aldh-pathway). ## The Dose Question Most retail DHM supplements use 100 to 300mg per serving. The published animal research, after surface-area conversion to human-equivalent doses and adjustment for DHM's poor bioavailability, points to roughly 1,500mg as the threshold where the enzyme effect actually shows up. That is not a small gap. It is the difference between a label number and a functional dose. The 100-300mg dose pattern persists across the supplement industry for one main reason: cost. DHM is not cheap, and a 1,500mg-per-serving formula is meaningfully more expensive to manufacture than a 200mg one. For the full math, see [DHM Dose-Response](/science/dhm/dose-response). For why the industry under-doses anyway, see [Why Most DHM Supplements Are Under-Dosed](/science/dhm/under-dosing-problem). ## DHM and Anxiety: The GABA Side DHM also acts on the GABA-A receptor system in the brain, which is the receptor system alcohol primarily targets. DHM is a positive modulator at the benzodiazepine binding site but, unlike actual benzodiazepines, it does not sedate at the doses that block alcohol's effects on the receptor. This combination matters because the morning-after anxiety that comes after even moderate drinking is largely a GABA-rebound story. Animal studies show DHM blunts both the acute alcohol response and the withdrawal-related anxiety that follows it, in the data we have so far at least. The mechanism is reproducible across labs but the human clinical data on DHM specifically for anxiety is still thin. For the full GABA story, see [DHM and GABA Modulation](/science/dhm/gaba-modulation). ## DHM and Brain Aging A separate line of DHM research focuses on neuroprotection and brain aging rather than acute alcohol effects. DHM crosses the blood-brain barrier, suppresses microglial inflammation in mouse models of Alzheimer's disease, and activates the AMPK/SIRT1 signaling pathway that protects against age-related neuronal stress[3]. The brain-aging research is preclinical only -- there are no human clinical trials of DHM for cognitive outcomes -- but the mechanisms are real and consistent across labs. This research is part of why we feel comfortable building the formula around DHM long-term. The compound has supporting evidence well outside the acute alcohol use case. For the full brain-aging story, see [DHM and Brain Aging](/science/dhm/brain-aging). ## How DHM Compares to Other Liver Supplements The three ingredients DHM most often gets compared against are milk thistle, prickly pear cactus extract, and N-acetylcysteine. Each has its own mechanism story and its own evidence base, and each has a different relationship to alcohol metabolism specifically. Milk thistle (silymarin) has decent evidence for fatty liver disease but weak evidence for alcohol-related outcomes. Prickly pear has one famous JAMA hangover study but works on inflammation rather than metabolism. NAC works mechanistically as a glutathione precursor but the human hangover-prevention trials are mixed and the effective dose is in the gram range. None of these act on ADH or ALDH directly the way DHM does, which is the published-evidence difference[2][4]. For the head-to-head pages, see [DHM vs. Milk Thistle](/science/dhm/vs-milk-thistle), [DHM vs. Prickly Pear](/science/dhm/vs-prickly-pear), and [DHM vs. NAC](/science/dhm/vs-nac). ## The Bioavailability Problem and the Delivery Solution DHM has a 4 percent absolute oral bioavailability problem, which is the actual reason most DHM products in the supplement aisle don't work even at the doses they claim. The molecule is poorly water-soluble adn chemically unstable in the gut. We address this in the formula in two ways: by raising the input dose to 1,500mg, and by pairing DHM with fulvic acid, which functions as a cellular delivery agent through chelation chemistry. The fulvic acid pairing is the part of the formula architecture that people ask about the least but that probably contributes the most to whether a given dose works for a given person. Bioavailability is a quiet variable, and also one of the most important ones. For the full bioavailability story, see [DHM Bioavailability](/science/dhm/bioavailability). For the fulvic acid delivery mechanism, see [DHM and Fulvic Acid -- The Delivery Mechanism](/science/dhm/dhm-fulvic-synergy). ## Where the Claims Land > **Claim [SF-21]:** Acts by promoting aldehyde and alcohol metabolism of foods. † > > † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. > **Claim [SF-01]:** Helps you feel fresh. † > > † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. > **Claim [SF-02]:** Supports overall liver health. † > > † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The structure-function claims H180 is permitted to make about DHM are narrow and specific. They follow the same metabolic pathway the published animal research describes, they are the claims we are confident defending in front of FDA reviewers, and they are the ones every sub-page in this cluster ties back to. ## Citations 1. Shen Y, et al. [Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication](https://pmc.ncbi.nlm.nih.gov/articles/PMC3292407/). PMC3292407. 2. Carneiro A, et al. [Does Dihydromyricetin Impact on Alcohol Metabolism?](https://pmc.ncbi.nlm.nih.gov/articles/PMC8603706/) PMC8603706. 3. Carry E, et al. [Preclinical Research of Dihydromyricetin for Brain Aging and Neurodegenerative Diseases](https://pmc.ncbi.nlm.nih.gov/articles/PMC6859532/). PMC6859532. 4. Silva J, et al. [Dihydromyricetin Protects the Liver via Changes in Lipid Metabolism and Enhanced Ethanol Metabolism](https://pmc.ncbi.nlm.nih.gov/articles/PMC7211127/). PMC7211127. ## All Pages In This Cluster - [What Is DHM](/science/dhm/what-is-dhm) - [How DHM Works: The ADH/ALDH Pathway](/science/dhm/adh-aldh-pathway) - [DHM Dose-Response](/science/dhm/dose-response) - [DHM and GABA Modulation](/science/dhm/gaba-modulation) - [DHM and Brain Aging](/science/dhm/brain-aging) - [DHM vs. Milk Thistle](/science/dhm/vs-milk-thistle) - [DHM vs. Prickly Pear](/science/dhm/vs-prickly-pear) - [DHM vs. NAC](/science/dhm/vs-nac) - [Why Most DHM Supplements Are Under-Dosed](/science/dhm/under-dosing-problem) - [DHM Bioavailability](/science/dhm/bioavailability) - [DHM and Fulvic Acid -- The Delivery Mechanism](/science/dhm/dhm-fulvic-synergy) - [Hovenia Dulcis -- The Source Plant](/science/dhm/hovenia-dulcis) - [DHM as a Flavonoid](/science/dhm/dhm-flavonoid) - [DHM Safety Profile](/science/dhm/safety-profile) - [Ampelopsis Grossedentata -- Vine Tea Source](/science/dhm/ampelopsis-grossedentata) ## Related Clusters - [The Formula](/science/formula) - [SAG -- S-Acetyl Glutathione](/science/sag) - [Fulvic Acid -- The Hub](/science/fulvic-acid) - [The Testing -- 150 Self-Experiments](/science/testing) **Written by Mark Scott** - Co-Formulator, Hangovr180® | Co-Inventor, [US Application 18/698,010](https://patents.google.com/patent/US20250073201A1) Mark Scott conducted approximately 150 personal formulation tests over six months to develop the H180 ingredient combination. [Editorial standards](/editorial-standards) --- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Hangovr180® is a dietary supplement. Individual results may vary. Consult your healthcare provider before use if you have any medical conditions or take medications. [US Application 18/698,010](https://patents.google.com/patent/US20250073201A1). Canonical: https://hangovr180.com/science/dhm