--- source_url: https://hangovr180.com/science/claims/liver-detoxification.md canonical_url: https://hangovr180.com/science/claims/liver-detoxification generated_at: 2026-06-28T19:53:17Z build_id: ebfcfef page_type: science-leaf claim_ids: [SF-30, SF-11, SF-20] --- # LIVER DETOXIFICATION *"Detoxification" is one of the most abused words in supplement marketing, but in the H180 case it ties to two specific and well-documented mechanisms: glutathione restoration and accelerated ethanol clearance.* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. ## What "Detoxification" Means in Biochemistry In biochemistry, detoxification refers to the cellular processes that convert toxic compounds (xenobiotics, metabolic byproducts, reactive species) into less toxic forms that the body can excrete. The liver is the primary detoxification organ, and the detoxification machinery includes phase I oxidation enzymes (CYP450s), phase II conjugation enzymes (glutathione S-transferases, sulfotransferases, glucuronosyltransferases), and the antioxidant systems that handle the reactive intermediates produced along the way. > **Claim [SF-30]:** Helps to detoxify your liver and other organs. † > > † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Glutathione sits at the center of this picture. It serves as the conjugation substrate for glutathione S-transferases (which handle a large fraction of phase II detoxification), as the cofactor for glutathione peroxidases (which neutralize reactive oxygen species and lipid peroxides), and as the redox buffer that keeps the rest of the system functional [1] [2]. (the word detoxification is used so loosely in the supplement industry that I almost did not want to include it on the label, but it has a specific biochemical meaning that maps cleanly to what the formula actually does.) ## How H180 Supports the Process > **Claim [SF-11]:** Elevates glutathione, the body's master antioxidant in the liver. † > > † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The SAG ingredient delivers intact glutathione across the gut wall and into liver cells where it joins both the cytoplasmic and mitochondrial GSH pools [1] [2]. This restores depleted GSH after ethanol exposure depletes it, which preserves the cell's capacity to perform conjugation and antioxidant detoxification. The DHM ingredient accelerates the upstream metabolism of ethanol and acetaldehyde, which reduces the total toxic load the GSH-dependent systems have to handle [3]. ## The AST/ALT Side of the Claim > **Claim [SF-20]:** Lowers liver enzyme (AST and ALT) levels that are already in the normal range. † > > † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. AST and ALT are serum markers of hepatocellular stress -- when liver cells are damaged, they release these enzymes into circulation. In animal models of ethanol exposure, DHM administration moves AST and ALT toward normal compared to ethanol-only controls [3], and a 2023 study examining DHM and ethanol-induced lipid accumulation reported similar improvements in liver injury markers and reductions in proinflammatory cytokines [4]. The supporting mechanism literature is reasonable for both the GSH-restoration and the enzyme-induction sides, in the published animal data at least. ## The Regulatory Framing The "already in the normal range" qualifier on the AST/ALT claim is the DSHEA-compliant way to describe a structure-function effect on a clinical marker. The claim cannot describe treatment of liver disease, but it can describe maintenance of values within the normal range, which is what the animal data on DHM in ethanol-exposed-but-otherwise-healthy rodents shows. The AST/ALT improvements in animal models support the bounded liver-enzyme claim adn nothing stronger. ## What This Page Is Not Claiming The detoxification claim is not "H180 cleanses your liver" or "H180 reverses liver damage." It is the narrower and more specific claim that the formula supports the cellular machinery that performs detoxification of food-derived compounds (including alcohol), through GSH restoration and enzyme induction. Both halves of that mechanism are documented in the published animal literature on the underlying ingredients. For the upstream enzyme-induction side, see [How DHM Works -- The ADH/ALDH Pathway](/science/dhm/adh-aldh-pathway). For the downstream antioxidant restoration side, see [Glutathione -- The Master Antioxidant](/science/sag/glutathione-master-antioxidant). ## Citations 1. [Changes in Glutathione Content in Liver Diseases -- An Update](https://pmc.ncbi.nlm.nih.gov/articles/PMC7997318/). pmc.ncbi.nlm.nih.gov. 2. [Mitochondrial Glutathione, a Key Survival Antioxidant](https://pmc.ncbi.nlm.nih.gov/articles/PMC2821140/). pmc.ncbi.nlm.nih.gov. 3. [Dihydromyricetin Protects the Liver via Changes in Lipid Metabolism and Enhanced Ethanol Metabolism](https://pmc.ncbi.nlm.nih.gov/articles/PMC7211127/). pmc.ncbi.nlm.nih.gov. 4. [Dihydromyricetin Supplementation Improves Ethanol-Induced Lipid Accumulation and Inflammation](https://pmc.ncbi.nlm.nih.gov/articles/PMC10481966/). pmc.ncbi.nlm.nih.gov. ## Read Next - [Aldehyde Metabolism Explained](/science/claims/aldehyde-metabolism) - [Glutathione -- The Master Antioxidant](/science/sag/glutathione-master-antioxidant) - [How DHM Works -- The ADH/ALDH Pathway](/science/dhm/adh-aldh-pathway) - [The Claims -- The Hub](/science/claims) **Written by Mark Scott** - Co-Formulator, Hangovr180® | Co-Inventor, [US Application 18/698,010](https://patents.google.com/patent/US20250073201A1) Mark Scott conducted approximately 150 personal formulation tests over six months to develop the H180 ingredient combination. [Editorial standards](/editorial-standards) --- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Hangovr180® is a dietary supplement. Individual results may vary. Consult your healthcare provider before use if you have any medical conditions or take medications. [US Application 18/698,010](https://patents.google.com/patent/US20250073201A1). Canonical: https://hangovr180.com/science/claims/liver-detoxification