--- source_url: https://hangovr180.com/science/claims/brain-aging-claim.md canonical_url: https://hangovr180.com/science/claims/brain-aging-claim generated_at: 2026-06-28T19:53:17Z build_id: ebfcfef page_type: science-leaf claim_ids: [SF-23, SF-26, SF-18] --- # THE BRAIN AGING CLAIM *The brain aging claim is the only Group 3 claim that depends on the brain-aging research literature rather than the alcohol-metabolism literature, and the framing is bounded carefully because the supporting evidence is preclinical.* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. ## What "Attenuates the Rate of Brain Aging" Means > **Claim [SF-23]:** Attenuates the rate of brain aging. † > > † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Brain aging in animal studies is operationalized as a combination of cognitive performance metrics, oxidative stress markers in brain tissue, neuroinflammation markers (microglial activation, inflammatory cytokine levels), and synaptic protein integrity. "Attenuates the rate" is the DSHEA-compliant phrasing for an intervention that, in animal data, moves these measures in the protective direction relative to untreated controls [1]. The 2019 preclinical review of DHM in brain aging and neurodegenerative disease covers the supporting literature across multiple disease models -- Alzheimer's, Parkinson's, and Huntington's -- and concludes that DHM has documented antioxidant, anti-inflammatory, and neuroprotective effects across the available animal studies [1]. (this is the claim where the regulatory bounded language matters most, because the supplement industry routinely overstates animal-model findings into human clinical claims.) ## The Two Mechanism Threads > **Claim [SF-26]:** Protects against occasional neuroinflammation. † > > † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The first supporting thread is anti-inflammatory. In APP/PS1 transgenic mice (a standard Alzheimer's disease model), DHM suppressed activation of the NLRP3 inflammasome in microglia and reduced markers of neuroinflammation [2]. Microglia are the immune cells of the brain, and chronic microglial activation is one of the cellular signatures of aging brain tissue. > **Claim [SF-18]:** Promotes brain health and cognitive function. † > > † These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The second supporting thread is energetic. DHM activates the AMPK/SIRT1 signaling pathway in neurons, which in plain terms means it pushes brain cells toward the metabolic state they sit in when young and well-rested rather than the state they drift into with age and oxidative stress [3]. The same study that mapped this in Alzheimer's-model rats reported reduced hippocampal cell death and improved cognitive performance on standard maze tasks. ## The Blood-Brain Barrier Question A 2021 mass-spec study identified intact DHM and its primary metabolites in mouse brain tissue after oral dosing, with kinetics consistent with the behavioral effects researchers had been measuring for years [4]. This matters because a lot of flavonoids never cross the blood-brain barrier in usable amounts. The brain-tissue concentration data establishes that whatever effect DHM has in animal brain studies is plausible at the doses studied -- the molecule actually reaches the relevant tissue. ## Where the Claim Stops The "attenuates the rate of brain aging" claim is not "DHM prevents Alzheimer's in humans" or "DHM enhances cognitive function in healthy adults." The brain-aging research is preclinical and the framing reflects that limitation, in the published animal data exclusively at least. The human clinical evidence si still thin, and the claim language reflects that boundary explicitly. ## What This Page Is Not Claiming We are not claiming DHM is a cognitive enhancer, a treatment for any neurodegenerative disease, or a substitute for medical care for cognitive symptoms. The claim is what the published animal mechanism literature supports, framed in DSHEA-compliant terms, and bounded by the preclinical nature of the underlying evidence base. For the full brain-aging story in the DHM cluster, see [DHM and Brain Aging](/science/dhm/brain-aging). For the closely related neuroinflammation claim in detail, see [The Inflammation Response Claim](/science/claims/inflammation-response). ## Citations 1. [Preclinical Research of Dihydromyricetin for Brain Aging and Neurodegenerative Diseases](https://pmc.ncbi.nlm.nih.gov/articles/PMC6859532/). pmc.ncbi.nlm.nih.gov. 2. [Dihydromyricetin Inhibits Microglial Activation and Neuroinflammation by Suppressing NLRP3 Inflammasome Activation in APP/PS1 Transgenic Mice](https://pmc.ncbi.nlm.nih.gov/articles/PMC6282966/). pmc.ncbi.nlm.nih.gov. 3. [Protective Role of Dihydromyricetin in Alzheimer's Disease Rat Model Associated with Activating AMPK/SIRT1 Signaling Pathway](https://pmc.ncbi.nlm.nih.gov/articles/PMC6328867/). pmc.ncbi.nlm.nih.gov. 4. [Identification of Dihydromyricetin and Metabolites in Serum and Brain Associated with Acute Anti-Ethanol Intoxicating Effects in Mice](https://pmc.ncbi.nlm.nih.gov/articles/PMC8307506/). pmc.ncbi.nlm.nih.gov. ## Read Next - [DHM and Brain Aging](/science/dhm/brain-aging) - [The Inflammation Response Claim](/science/claims/inflammation-response) - [Aldehyde Metabolism Explained](/science/claims/aldehyde-metabolism) - [The Claims -- The Hub](/science/claims) **Written by Mark Scott** - Co-Formulator, Hangovr180® | Co-Inventor, [US Application 18/698,010](https://patents.google.com/patent/US20250073201A1) Mark Scott conducted approximately 150 personal formulation tests over six months to develop the H180 ingredient combination. [Editorial standards](/editorial-standards) --- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Hangovr180® is a dietary supplement. Individual results may vary. Consult your healthcare provider before use if you have any medical conditions or take medications. [US Application 18/698,010](https://patents.google.com/patent/US20250073201A1). Canonical: https://hangovr180.com/science/claims/brain-aging-claim