Beyond Hangovers: DHM's Impact on Aging
Dec 11, 2024
Dihydromyricetin (DHM), the primary active ingredient in Hangovr180, is gaining attention not just for its hangover-preventing properties but for its potential impact on longevity and healthspan. Recent research has revealed that DHM's mechanisms of action align closely with several key hallmarks of aging, positioning it as a promising compound in the field of longevity science.
Addressing Multiple Hallmarks of Aging
The 2023 publication "Hallmarks of aging: An expanding universe" outlines twelve hallmarks that drive the aging process.
Remarkably, DHM has been shown to influence several of these hallmarks:
Genomic Instability and Epigenetic Alterations
DHM exhibits potent antioxidant properties, which may help protect against genomic instability caused by oxidative stress. Studies have demonstrated DHM's free radical scavenging abilities, suggesting a potential role in maintaining genomic integrity.
Mitochondrial Dysfunction
Mitochondrial health is crucial for longevity. DHM has been shown to enhance mitochondrial function, potentially through its effects on key signaling pathways such as AMPK and SIRT1. This improvement in cellular energy production could contribute to overall healthspan enhancement.
Deregulated Nutrient Sensing
DHM's impact on metabolic pathways is particularly noteworthy. Research indicates that it may influence insulin sensitivity and glucose metabolism, potentially addressing the hallmark of deregulated nutrient sensing. This effect could have far-reaching implications for metabolic health and longevity.
Cellular Senescence and Chronic Inflammation
One of the most promising aspects of DHM is its potential to modulate cellular senescence and inflammation. Studies have shown that DHM can reduce inflammatory markers and may help mitigate the accumulation of senescent cells, both key factors in the aging process.
Hepatoprotective Effects
DHM has demonstrated significant liver-protective properties, potentially safeguarding against various forms of liver damage. This is particularly relevant given the liver's crucial role in detoxification and overall health.
Neuroprotection
Emerging research suggests that DHM may have neuroprotective effects, potentially contributing to cognitive health and resilience against age-related neurological decline.
Cardiovascular Health
DHM's impact on metabolic health extends to cardiovascular benefits, with studies indicating potential improvements in lipid profiles and vascular function.